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How do Sildenafil Citrate Tablets Work?

This medication works by inhibiting an enzyme called PDE5 that is found in several tissues, especially the smooth muscle cells lining the blood vessels of the penis. This enzyme breaks down another beneficial enzyme for erectile function called cGMP. So, by blocking PDE5, levels of cGMP can accumulate and this improves the body’s ability to produce nitric oxide. Nitric oxide dilates blood vessels which improves blood supply to the penis leading to improved erectile function.

 

Sildenafil Tablets – A Safe Treatment Option

A comprehensive study reported the discontinuation rate of Sildenafil due to side effects was 2.5% for sildenafil citrate and 2.3% for placebo-based pills. Placebo is an inert substance with no effect like sugar or starch. The difference in discontinuation rates between placebo and sildenafil shows that a large number of patients are not deterred by side effects which ultimately make Sildenafil a safe and effective choice. Common side effects usually occur due to incorrect use, doses; and contraindications which affect a mere 10% of people. That being said, side effects are rare and if experienced, they are tolerable and can be self-managed.

What is Sildenafil?

Sildenafil is a treatment that comes from the commonly known Viagra brand. Its main ingredient sildenafil citrate plays an important role in the treatment of erectile dysfunction. The medication ensures positive results and interacts well with normal metabolic processes. The treatment requires direct physical and mental stimulation and is usually used in planned or unplanned sex as effects start to show 30 minutes after consumption and can last for up to 6 hours.

Both Viagra and Sildenafil generic have been proven to be equally effective in the treatment of erectile dysfunction. Viagra is the brand name for Sildenafil generic and while ED-treatment is the primary focus, it is also used to treat erectile pulmonary arterial hypertension.

 

When should Sildenafil Not be Used?

It is usually not advisable to take this medicine if you:

  • Have any known previous allergic reactions to Sildenafil or similar medicines containing the active ingredient.
  • Have low blood pressure.
  • Have had a history of heart attacks, angina or stroke.
  • Are currently taking other medications for ED.
  • Are using any medicines that contain nitrates, as this can react negatively with Sildenafil.
  • Have serious liver or heart problems.
  • Have a blood cell disorder such as sickle cell anemia.
  • Have been told you should not have sexual intercourse for health reasons.

 

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